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Cytokine storm and translating IL-6 biology into effective treatments for COVID-19
《医学前沿(英文)》 doi: 10.1007/s11684-023-1044-4
关键词: SARS-CoV-2 COVID-19 cytokine storm interleukin-6 tocilizumab
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 139-145 doi: 10.1007/s11684-015-0377-z
In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissue function. Although this view is supported by a large body of literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulin sensitivity through induction of energy expenditure. In this review article, interleukin 15 (IL-15) is used as a new example to explain the beneficial effects of the pro-inflammatory cytokines. IL-15 is secreted by multiple types of cells including macrophages, neutrophils and skeletal muscle cells. IL-15 expression is induced in immune cells by endotoxin and in muscle cells by physical exercise. Its transcription is induced by transcription factor NF-κB. IL-15 binds to its receptor that contains three different subunits (α, β and γ) to activate JAK/STAT, PI3K/Akt, IKK/NF-κB and JNK/AP1 pathways in cells. In the regulation of metabolism, IL-15 reduces weight gain without inhibiting food intake in rodents. IL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight loss and energy expenditure. In human, circulating IL-15 is negatively associated with body weight. In the immune system, IL-15 stimulates proliferation and differentiation of T cells, NK cells, monocytes and neutrophils. In the anti-obesity effects of IL-15, T cells and NK cells are not required, but leptin receptor is required. In summary, evidence from human and rodents supports that the pro-inflammatory cytokine IL-15 may enhance energy expenditure to protect the body from obesity and type 2 diabetes. The mechanism of IL-15 action remains to be fully uncovered in the regulation of energy expenditure.
关键词: inflammation obesity cytokine energy expenditure insulin resistance
人工肝血液净化系统——一种针对COVID-19细胞因子风暴的有效救治方法
章益民, 俞亮, 汤灵玲, 朱梦飞, 金燕琪, 王周晗, 李兰娟
《工程(英文)》 2021年 第7卷 第1期 页码 11-13 doi: 10.1016/j.eng.2020.03.006
《结构与土木工程前沿(英文)》 2021年 第15卷 第6期 页码 1301-1316 doi: 10.1007/s11709-021-0765-1
中药治疗新冠病毒肺炎的科学基础 Perspective
梁丽娴, 潘胡丹, 黄虞枫, 范星星, 王婉莹, 何芳, 蔡俊, 周华, 刘良
《工程(英文)》 2020年 第6卷 第10期 页码 1099-1107 doi: 10.1016/j.eng.2020.08.009
新近暴发的新冠病毒肺炎(COVID-19)已成为危害全球健康的紧急事件。现有证据表明,新冠病毒(SARS-CoV-2)与其他冠状病毒(如SARS-CoV和MERS-CoV)的基因序列具有相似性。因此, 针对现存冠状病毒的引发疾病的机制研究和在治疗SARS时所取得的经验和教训,可咨今天对抗新冠病毒引发疾病的参考。COVID-19患者的临床病理特征提示患者在病情进展过程中通常会经历五个发展阶段:大量病毒感染、免疫系统抑制、细胞因子风暴、多器官损伤及后期的肺纤维化样改变, 严重者常导致死亡。早期阻断疾病进展是取得治疗成功的关键。但是,目前尚无针对COVID-19的 特效药物或疫苗,世界卫生组织(WHO)正敦促尽快建立新型预防和治疗策略。传统中医药(TCM) 对于疫病的防治的实践已经积累了几千年的有用经验,它通过整体调节机体功能发挥疗效。在此次疫情中,中医药作为替代治疗或与西药联合使用,在疫情防控中发挥了重要的作用。本文总结了此次抗疫过程中中国国家和省级机构推荐使用的中药复方和中成药的潜在用途和治疗机制,以期发现其治疗COVID-19的潜在科学内涵。同时,整合应用多种组学及转化医学技术开展基础与临床研究有望进一步证实中药复方的治疗机制。
Inflammation and liver tumorigenesis
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 242-254 doi: 10.1007/s11684-013-0256-4
Inflammation has been considered as one of the hallmarks of cancer, and chronic hepatitis is a major cause of liver cancer. This review will focus on the pathogenic role of inflammation in hepatocarcinogenesis and will discuss recent advances in understanding the chronic hepatitis-liver cancer link based on hot spots in liver cancer research, including cellular interaction, cytokines, microRNA and stem cells. All of these mechanisms should be taken into consideration because they are crucial for the development of more efficacious therapeutic strategies for preventing and treating human chronic hepatitis and hepatocellular carcinoma.
关键词: hepatocellular carcinoma hepatitis cytokine stem cell miRNA
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
《医学前沿(英文)》 2019年 第13卷 第1期 页码 69-82 doi: 10.1007/s11684-018-0677-1
Cytokine-activated T cells (CATs) can be easily expanded and are widely applied to cancer immunotherapy. However, the good efficacy of CATs is rarely reported in clinical applications because CATs have no or very low antigen specificity. The low-efficacy problem can be resolved using T cell antigen receptor-engineered CAT (TCR-CAT). Herein, we demonstrate that NY-ESO-1157–165 HLA-A*02:01-specific high-affinity TCR (HAT)-transduced CATs can specifically kill cancer cells with good efficacy. With low micromolar range dissociation equilibrium constants, HAT-transduced CATs showed good specificity with no off-target killing. Furthermore, the high-affinity TCR-CATs delivered significantly better activation and cytotoxicity than the equivalent TCR-engineered T cells (TCR-Ts) in terms of interferon-g and granzyme B production and in vitro cancer cell killing ability. TCR-CAT may be a very good alternative to the expensive TCR-T, which is considered an effective personalized cyto-immunotherapy.
关键词: cytokine-activated T cells high-affinity T cell receptor cancer immunotherapy TCR-CAT
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
《农业科学与工程前沿(英文)》 2015年 第2卷 第1期 页码 73-83 doi: 10.15302/J-FASE-2015044
Soumendra Nath KUIRY, Yan DING, Sam S Y WANG
《结构与土木工程前沿(英文)》 2014年 第8卷 第1期 页码 57-68 doi: 10.1007/s11709-014-0235-0
关键词: coastal inlet coastal process modeling supercritical flow sediment transport barrier islands
Zhang Harry, Yu Shaw
《环境科学与工程前沿(英文)》 2008年 第2卷 第3期 页码 267-273 doi: 10.1007/s11783-008-0058-0
关键词: representative hydrologic occurrence simulation approach scarcity alternative
Management of cytokine release syndrome related to CAR-T cell therapy
Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He
《医学前沿(英文)》 2019年 第13卷 第5期 页码 610-617 doi: 10.1007/s11684-019-0714-8
关键词: chimeric antigen receptor T cell cytokine release syndrome tocilizumab
任阵海,高庆先,苏福庆,王耀庭,张志刚,杨新兴
《中国工程科学》 2003年 第5卷 第2期 页码 49-56
讨论了北京大气环境的区域性特征。利用网络点集确定出大气输送通道,提出了汇聚带概念,同时分析了北京地区大气污染特征,使用激光技术探测了大气气溶胶的垂直分布。研究表明北京大气环境质量与周边地区的污染源有密切的关系,认为只有进行同步治理才能有效地改善首都大气环境的质量。通过卫星监测技术和对气象流场进行分析,对我国沙尘暴现象进行了研究。指出境外沙尘源和境内沙尘源,并以2002年3月20日北京一次特强沙尘暴为例,对原始沙尘源的分布进行了解析,分析指出原始沙尘源包括春季长江以北广大的裸露土地,显示出沙尘暴起始过程是以点源群出现,然后合并为沙尘带,最后出现大面积沙尘污染。并简述了我国现代环境理念。
王雪臣,程磊
《中国工程科学》 2004年 第6卷 第3期 页码 64-67
沙尘暴是一种灾害性天气,对我国国民经济和人民生活产生了严重影响。加强沙尘暴监测预警服务工作是利国利民之举,意义深远。目前的监测预报能力尚存在不足,不能满足对沙尘暴进行定量实时监测和预报的要求。通过沙尘暴监测预警服务系统一期工程建设可以明显增强对沙尘暴的监测预警服务能力。一期工程建设主要包括监测分系统、预警服务分系统、通信传输分系统等部分。为确保该项目建设效益的发挥,该项目的建设要充分发挥现有台站的监测能力,并考虑系统功能的整体性、可拓展性和资料格式的标准化等问题。
标题 作者 时间 类型 操作
Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes
null
期刊论文
Integrating storm surge modeling with traffic data analysis to evaluate the effectiveness of hurricane
期刊论文
High-affinity T cell receptors redirect cytokine-activated T cells (CAT) to kill cancer cells
Synat Kang, Yanyan Li, Yifeng Bao, Yi Li
期刊论文
Molecular characterization of two suppressor of cytokine signaling 1 genes (
Xue XU,Jiannan ZHANG,Juan LI,Yajun WANG
期刊论文
Numerical simulations of morphological changes in barrier islands induced by storm surges and waves using
Soumendra Nath KUIRY, Yan DING, Sam S Y WANG
期刊论文
Critical flow-storm approach to total maximum daily load (TMDL) development: an analytical conceptual
Zhang Harry, Yu Shaw
期刊论文
Management of cytokine release syndrome related to CAR-T cell therapy
Hongli Chen, Fangxia Wang, Pengyu Zhang, Yilin Zhang, Yinxia Chen, Xiaohu Fan, Xingmei Cao, Jie Liu, Yun Yang, Baiyan Wang, Bo Lei, Liufang Gu, Ju Bai, Lili Wei, Ruili Zhang, Qiuchuan Zhuang, Wanggang Zhang, Wanhong Zhao, Aili He
期刊论文